Advances in the research of cerebral small vessel disease and motor dysfunction in Parkinson’s disease WANG Xiaojun，PENG Huiyuan Zhongshan Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine，Zhongshan 528400，China Corresponding author：PENG Huiyuan 【Abstract】 Parkinson’s disease（PD）is a neurodegenerative disease with the pathological hallmark of selective loss of dopaminergic neurons in the substantia nigra，with motor dysfunction as one of its characteristic manifestations. Cerebral small vessel disease（CSVD）is a series of clinical and imaging syndromes caused by structural and functional changes in the small intracranial arteries and microvasculature. Recent studies have found comorbid between the PD and CSVD，and Parkinson’s disease patients with combined CSVD show more significant motor impairment.However，This group of patients has not received sufficient attention from clinical workers. In this paper，we review the progress of clinical research related to movement disorders and cerebral small vessel disease in the patients with Parkinson’s disease. 【Key words】 Parkinson’s disease；Cerebral small vessel disease；Motor dysfunction；Prevention；Progression
